OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis

• DOI: 10.1073/pnas.1321071111
• Publication Date: 2014-01-28T05:29:52Z
• Authors: Emily Gwyer Findlay; Lynett Danks; Jodie Madden; Mary M. Cavanagh; Kay McNamee; Fiona McCann; Robert J. Snelgrove; Stevan Shaw; Marc Feldmann; Peter Charles Taylor; Nicole J. Horwood; Tracy Hussell
• Keywords: 0303 health sciences; Membrane Glycoproteins; 610; Antibodies, Monoclonal; Osteoclasts; OX40 Ligand; 3. Good health; Arthritis, Rheumatoid; Mice; 03 medical and health sciences; 616; Tumor Necrosis Factors; Animals; Cytokines; Homeostasis; Tumor Necrosis Factor Inhibitors; Inflammation Mediators; Signal Transduction

Significance Current therapies to alleviate autoimmune conditions use global strategies that affect large compartments of the immune response. These strategies mop up the excesses of disease without slowing disease progression and carry a significant risk of infection. This article describes the selective inhibition of autoaggressive T cells with the ability to regress established arthritis and reveals an unexpected role for an immune receptor–ligand pair in bone homeostasis.