Hierarchical expression of genes controlled by theBacillus subtilisglobal regulatory protein CodY

• DOI: 10.1073/pnas.1321308111
• Publication Date: 2014-05-20T02:36:03Z
• Authors: Shaun R. Brinsmade; Elizabeth L. Alex...; Jonathan Livny; Arion I. Stettner; Daniel Segrè; Kyu Y. Rhee; Abraham L. Sonens...
• Keywords: 0301 basic medicine; Sequence Analysis, RNA; Glutamic Acid; Gene Expression Regulation, Bacterial; Arginine; Ligands; Carbon; 03 medical and health sciences; Bacterial Proteins; Escherichia coli; Transaminases; Bacillus subtilis; Transcription Factors

SignificanceThis report reveals that the more than 200 genes controlled byBacillus subtilisglobal regulatory protein CodY are controlled in a hierarchical manner that reflects the extent of activation of CodY by its ligands. The results suggest thatB. subtilisuses hierarchical regulation by CodY to achieve strategic goals.