IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

• DOI: 10.1073/pnas.1322831111
• Publication Date: 2014-02-19T01:52:24Z
• Authors: Antonella de Luca; Sanne P. Smeekens; Andrea Casagrande; Rossana Iannitti; Kara L. Conway; Mark. S. Gresnigt; Jakob Begun; Theo S. Plantinga; Leo A. B. Joosten; Jos W. M. van der...; Georgios Chamilos; Mihai G. Netea; Ramnik J. Xavier; Charles A. Dinarello; Luigina Romani; Frank L. van de V...
• Keywords: Chronic Granulomatous Disease

Significance Chronic granulomatous disease (CGD) has an immunodeficiency component and, in addition, autoinflammatory which autophagy and inflammasome activation are linked amenable to IL-1 blockade. This study provides a rationale perform clinical trials investigate the efficacy of blocking CGD colitis expands therapeutic potential antagonists inflammatory diseases with defective autophagy.