Differential expression of estrogen receptor α, β1, and β2 in lobular and ductal breast cancer

• DOI: 10.1073/pnas.1323719111
• Publication Date: 2014-01-22T04:02:30Z
• Authors: Bo Huang; Yoko Omoto; Hirotaka Iwase; Hiroko Yamashita; Tatsuya Toyama; Raoul Charles Coo...; Aleksandra Filipovic; Margaret Warner; Jan-Åke Gustafsson
• Keywords: Lobular carcinoma; Invasive lobular carcinoma

Significance Whether breast cancer will respond to the antiestrogen tamoxifen is determined by whether cellular proliferation estrogen receptor (ER) α-mediated. As opposed early ductal cancer, which an ERα-rich, proliferating disease, in lobular both ERα and ERβ are abundantly expressed rare. In advanced lost, retained, high. Thus, may be effective pharmaceutical late but not cancer.