Uncoupling reproduction from metabolism extends chronological lifespan in yeast

• DOI: 10.1073/pnas.1323918111
• Publication Date: 2014-04-01T06:13:03Z
• Authors: Saisubramanian Na...; Arthur L. Kruckeberg; Karen H. Schmidt; Evgueny Kroll; Morgan Hamilton; Kate McInnerney; Ryan Summers; Timothy Taylor; Frank Rosenzweig
• Keywords: Calorie Restriction; Cell metabolism; Calorie

Significance All cells age and do so in relation to how many times a cell divides (replicative aging) long nondividing can live (chronological aging). Bakers’ yeast has been used study both, but because when nutrient levels permit, the genetics of its chronological lifespan only studied under calorie restriction, mimicked by starvation. Because terminally differentiated animal are long-lived rarely starve, we developed model calorie-unrestricted conditions. When encapsulated fed ad libitum, goes into cycle arrest, continues be metabolically active, remains viable for weeks, offering new experimental paradigm absence restriction.