Using constellation pharmacology to define comprehensively a somatosensory neuronal subclass
TRPM8
DOI:
10.1073/pnas.1324019111
Publication Date:
2014-01-28T05:29:52Z
AUTHORS (4)
ABSTRACT
Significance Change in the nervous system occurs response to diverse inputs, both normal and pathological. Defining such changes is required for understanding nervous-system functions pathologies—e.g., from learning memory intractable disease. A unique combination pharmacology strategy allows identification of distinct neuronal subclasses through their constant functional expression a specific subset signaling proteins. Phenotypic alterations one subclass were tracked as function development. These provide proof-of-principle that individual types neurons can be monitored learning, disease, or aging. Developing biomarkers therapeutic interventions pathologies will require simultaneously monitoring different early during disease progression.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (33)
CITATIONS (49)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....