Using constellation pharmacology to define comprehensively a somatosensory neuronal subclass

• DOI: 10.1073/pnas.1324019111
• Publication Date: 2014-01-28T05:29:52Z
• Authors: Russell W. Teichert; Tosifa Memon; Joseph W. Aman; Baldomero M. Olivera
• Keywords: TRPM8

Significance Change in the nervous system occurs response to diverse inputs, both normal and pathological. Defining such changes is required for understanding nervous-system functions pathologies—e.g., from learning memory intractable disease. A unique combination pharmacology strategy allows identification of distinct neuronal subclasses through their constant functional expression a specific subset signaling proteins. Phenotypic alterations one subclass were tracked as function development. These provide proof-of-principle that individual types neurons can be monitored learning, disease, or aging. Developing biomarkers therapeutic interventions pathologies will require simultaneously monitoring different early during disease progression.