Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin

• DOI: 10.1073/pnas.1324035111
• Publication Date: 2014-05-20T02:36:03Z
• Authors: Mikołaj Ogrodnik; Hanna Salmonowicz; Rachel Brown; Joanna Turkowska; Władysław Średniawa; Sundararaghavan P...; Triana Amen; Ayelet-chen Abraham; Noam Eichler; Roman Lyakhovetsky; Daniel Kaganovich
• Keywords: Aggresome; Inclusion bodies; Polarity (international relations)

Significance We show, for the first time to our knowledge, that vimentin intermediate filaments establish mitotic polarity in dividing mammalian cell lines. By confining damaged, misfolded, and aggregated proteins JUNQ inclusion bodies, mediates their asymmetric partitioning during division. also, provide direct evidence of active proteasomal degradation dynamic bodies. This work sheds light on an important rejuvenation mechanism cells provides new biological insight into role bodies regulating aggregation, toxicity, aging.