A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

• DOI: 10.1073/pnas.1332764100
• Publication Date: 2003-07-08T19:18:15Z
• Authors: Zirong Li; Sara Van Calcar; Chunxu Qu; Webster K. Cavenee; Michael Q. Zhang; Bing Ren
• Keywords: Transcription

Overexpression of c-Myc is one the most common alterations in human cancers, yet it not clear how this transcription factor acts to promote malignant transformation. To understand molecular targets function, we have used an unbiased genome-wide location-analysis approach examine genomic binding sites Burkitt's lymphoma cells. We find that together with its heterodimeric partner, Max, occupy >15% gene promoters tested these cancer The DNA and Max correlates extensively expression throughout genome, a hallmark attribute general factors. c-Myc/Max heterodimer complexes also colocalize IID cells, further supporting role for overexpressed global regulation. In addition, majority target genes exhibits changes correlated levels c- myc mRNA diverse set tissues cell lines, conclusion regulates them. Taken together, results suggest transcriptional regulation some cells point toward mechanisms function