Molecular basis for AUXIN RESPONSE FACTOR protein interaction and the control of auxin response repression

• DOI: 10.1073/pnas.1400074111
• Publication Date: 2014-03-26T01:11:36Z
• Authors: David A. Korasick; Corey S. Westfall; Soon Goo Lee; Max H. Nanao; Renaud Dumas; Gretchen Hagen; Thomas J. Guilfoyle; Joseph M. Jez; Lucia C. Strader
• Keywords: 580; 570; crystal structure; 0303 health sciences; Arabidopsis thaliana; Indoleacetic Acids; Sequence Homology, Amino Acid; [SDV.BBM]Life Sciences [q-bio]/Biochemistry; Molecular Sequence Data; Arabidopsis; plant; phytohormone; 03 medical and health sciences; Mutation; gene expression; [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology; Amino Acid Sequence; auxin; Molecular Biology; transcription factor; Plant Proteins

SignificanceAuxin is a critical plant hormone that regulates every aspect of plant growth and development. AUXIN RESPONSE FACTOR (ARF) transcription factors control auxin-regulated gene transcription, and their activity is regulated by AUXIN/INDOLE 3-ACETIC ACID repressor proteins. This work identifies that dimerization of the repressor with the transcription factor is insufficient to repress activity, suggesting that multimerization is the mechanism of repressing ARF transcriptional activity and further raising the possibility that multimerization in other systems may play roles in transcriptional repression.