Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

• DOI: 10.1073/pnas.1400889111
• Publication Date: 2014-03-04T02:26:27Z
• Authors: Milène Catoire; Sheril Alex; Nicolas Paraskevo...; Frits Mattijssen; Inkie Evers-van Gogh; Gert Schaart; Jacob Jeppesen; Anita Kneppers; Marco Mensink; Peter J. Voshol; Gunilla Olivecrona; Nguan Soon Tan; Matthijs K. C. He...; Jimmy F. Berbée; Patrick C. N. Rensen; Eric Kalkhoven; Patrick Schrauwen; Sander Kersten
• Keywords: ANGPTL4; Homeostasis

Significance Physical exercise causes profound changes in energy metabolism humans. In this study we show that resting skeletal muscle has a crucial role the metabolic response to acute exercise. During endurance exercise, selective induction of protein angiopoietin-like 4 (ANGPTL4) nonexercising reduces local fatty acid uptake, presumably prevent fat overload, while directing acids active as fuel. Our data thus suggest key governing lipid homeostasis during