Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABA A receptors

• DOI: 10.1073/pnas.1403285111
• Publication Date: 2014-04-29T07:37:37Z
• Authors: Armen M. Abramian; Eydith Comenencia...; Amit Modgil; Thuy N. Vien; Yasuko Nakamura; Yvonne E. Moore; Jamie L. Maguire; Miho Terunuma; Paul A. Davies; Stephen J. Moss
• Keywords: Allopregnanolone; Tonic (physiology); Allosteric modulator

Significance This study provides an understanding of how neurosteroids regulate the membrane expression α4 subunit-containing extrasynaptic GABA A receptor (GABA R) subtypes that mediate tonic inhibition. is significant because it defines unexpected molecular mechanism by which produce long-lasting changes in efficacy GABAergic expected to lead development pharmacological strategies can control number Rs on cell surface. These hold promise restoring inhibition diseases are associated with a reduced boosting alleviate broad range neuropsychiatric disorders.