Pla2g16 phospholipase mediates gain-of-function activities of mutant p53

Phospholipase D
DOI: 10.1073/pnas.1404139111 Publication Date: 2014-07-15T05:15:59Z
ABSTRACT
Significance Mutations of p53 occur in approximately 50% human cancer. missense mutations exhibit gain-of-function activities. In this study, we discovered a previously unidentified mechanism mutant osteosarcoma and mammary tumors. Our data indicate that binds to E26 transformation-specific motifs the Pla2g16 phospholipase promoter induce its expression, which leads more aggressive metastatic phenotypes. Thus, study implicates regulation lipid metabolism cancer cells confer gain-of-function. The suggests new therapeutic options for patients with p53.
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