Pla2g16 phospholipase mediates gain-of-function activities of mutant p53

• DOI: 10.1073/pnas.1404139111
• Publication Date: 2014-07-15T05:15:59Z
• Authors: Shunbin Xiong; Huolin Tu; Madhusudhan Kolla...; Vinod Pant; Qin Li; Yun Zhang; James G. Jackson; Young-Ah Suh; Ana C. Elizondo-F...; Peirong Yang; Gilda Chau; Mehrnoosh Tashakori; Amanda R. Wasylishen; Zhenlin Ju; Hilla Solomon; Varda Rotter; Bin Liu; Adel K. El-Naggar; Lawrence A. Doneh...; Luis Alfonso Mart...; Guillermina Lozano
• Keywords: Phospholipase D

Significance Mutations of p53 occur in approximately 50% human cancer. missense mutations exhibit gain-of-function activities. In this study, we discovered a previously unidentified mechanism mutant osteosarcoma and mammary tumors. Our data indicate that binds to E26 transformation-specific motifs the Pla2g16 phospholipase promoter induce its expression, which leads more aggressive metastatic phenotypes. Thus, study implicates regulation lipid metabolism cancer cells confer gain-of-function. The suggests new therapeutic options for patients with p53.