Tsc1 promotes the differentiation of memory CD8 + T cells via orchestrating the transcriptional and metabolic programs

• DOI: 10.1073/pnas.1404264111
• Publication Date: 2014-10-01T08:24:31Z
• Authors: Sharad Shrestha; Kai Yang; Jun Wei; Peer W. F. Karmaus; Geoffrey Neale; Hongbo Chi
• Keywords: Transcription, Genetic; Gene Expression Profiling; TOR Serine-Threonine Kinases; Tumor Suppressor Proteins; Cell Differentiation; CD8-Positive T-Lymphocytes; Mechanistic Target of Rapamycin Complex 1; Tuberous Sclerosis Complex 1 Protein; 3. Good health; Mice, Inbred C57BL; 03 medical and health sciences; 0302 clinical medicine; Gene Expression Regulation; Multiprotein Complexes; Animals; Antigens; Immunologic Memory

Significance Enhancing the generation and function of memory T cells represents a crucial strategy to improve protective immunity against pathogens tumors. The signaling pathway via mechanistic target rapamycin (mTOR) has been implicated in regulation differentiation effector cells, but upstream regulators or downstream mechanisms remain unclear. In this study, we provide insight into basis that controls mTOR T-cell responses. deficiency tuberous sclerosis 1 (Tsc1) antigen-experienced impairs precursors formation associated with excessive activity dysregulated cell metabolism. Our study establishes molecular mechanism links metabolism for development.