Hit-and-run transcriptional control by bZIP1 mediates rapid nutrient signaling in Arabidopsis

• DOI: 10.1073/pnas.1404657111
• Publication Date: 2014-06-24T08:39:14Z
• Authors: Alessia Para; Ying Li; Amy Marshall-Colón; Kranthi Varala; Nancy J. Francoeur; Tara M. Moran; Molly B. Edwards; Christopher Hackley; Bastiaan O. R. Ba...; Kenneth D. Birnbaum; W. Richard McCombie; Gabriel Krouk; Gloria M. Coruzzi
• Keywords: Transient (computer programming)

Significance Cellular signals evoke rapid and broad changes in gene regulatory networks. To uncover these network dynamics, we developed an approach able to monitor primary targets of a transcription factor (TF) based solely on regulation, the absence detectable binding. This enabled us follow transient propagation nitrogen (N) nutrient signal as direct impact master TF Basic Leucine Zipper 1 (bZIP1). Unexpectedly, largest class that exhibit associations with bZIP1 is uniquely relevant dynamic N signal. Our ability this architecture has revealed “dark matter” signaling plants previously eluded detection.