An iron-regulated and glycosylation-dependent proteasomal degradation pathway for the plasma membrane metal transporter ZIP14

• DOI: 10.1073/pnas.1405355111
• Publication Date: 2014-06-10T07:46:19Z
• Authors: Ningning Zhao; An-Sheng Zhang; Christal Worthen; Mitchell D. Knutson; Caroline A. Enns
• Keywords: Endoplasmic-reticulum-associated protein degradation; Protein Degradation; Transport protein

Significance The canonical degradation pathway for plasma membrane proteins is through endocytosis and targeting to lysosomes. In some cases, undergo retrograde trafficking the endoplasmic reticulum (ER) extraction an reticulum-associated pathway. We identified a novel proteasome-mediated of iron transporter, ZIP14. Extraction ZIP14 occurred after endocytosis, but did not occur by ER. Both ubiquitination deglycosylation were prior degradation. To our knowledge, first multispanning protein such addition, we showed that regulated cellular content, providing insight into disorders metabolism.