Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma

• DOI: 10.1073/pnas.1406985111
• Publication Date: 2014-10-07T02:54:30Z
• Authors: Stephan Kreher; M. Amine Bouhlel; Pierre Cauchy; Björn Lamprecht; Shuang Li; Michael Grau; Franziska Hummel; Karl Köchert; Ioannis Anagnosto...; Korinna Jöhrens; Michael Hummel; John Hiscott; Sören-Sebastian W...; Peter Lenz; Markus Schneider; Ralf Küppers; Claus Scheidereit; Maciej Giefing; Reiner Siebert; Klaus Rajewsky; Georg Lenz; Peter N. Cockerill; Martin Janz; Bernd Dörken; Constanze Bonifer; Stephan Mathas
• Keywords: IRF5; PAX5; IRF4

Significance Human lymphomas and leukemias are characterized by molecular structural alterations of transcription factors (TFs). The identification such deregulated TFs is therefore central to the understanding lymphomagenesis. We addressed this question in classical Hodgkin lymphoma (HL), a common B-cell–derived malignancy that one most prominent examples for complex patterns including activation NF-κB or AP-1 profound deregulation lineage-specific TFs. found IRF5 together with induces number HL characteristic features non-Hodgkin cells, as expression cytokines chemokines activation. Our work exemplifies how global type-specific characterization TF activities can improve tumor biology.