Role for LSM genes in the regulation of circadian rhythms

• DOI: 10.1073/pnas.1409791111
• Publication Date: 2014-10-07T02:54:30Z
• Authors: Soledad Perez-San...; Estefanía Mancini; Lauren J. Francey; Ruben Gustavo Sch...; Ariel Chernomoretz; John B. Hogenesch; Marcelo J. Yanovsky
• Keywords: Clockwork; Spliceosome

Significance There is increasing evidence that previously considered core constituents of multi-subunit complexes involved in RNA processing play regulatory rather than passive roles the control gene expression, but specific signaling pathways which they participate are not known. Here we show SM-like ( LSM ) genes, encode components spliceosome, regulated by circadian clock and function plants mammals, revealing convergent evolutionary mechanisms mediating posttranscriptional regulation networks across kingdoms.