Genetic modifiers of EGFR dependence in non-small cell lung cancer

• DOI: 10.1073/pnas.1412228112
• Publication Date: 2014-12-16T03:25:14Z
• Authors: Tanaz Sharifnia; Victor Rusu; Federica Piccioni; Mukta Bagul; Marcin Imielinski; Andrew D. Cherniack; Chandra Sekhar Pe...; Bang Wong; Frederick H. Wilson; Levi A. Garraway; David Altshuler; Todd R. Golub; David E. Root; Aravind Subramanian; Matthew Meyerson
• Keywords: EGFR Inhibitors; ERBB3; Cyclin-dependent kinase 8

Significance Non-small cell lung cancers (NSCLCs) harboring mutations in the epidermal growth factor receptor ( EGFR ) gene are often singularly reliant on activity for tumor survival, but genetic basis this dependence is not fully understood. In study, we have performed a screen to identify spectrum of kinase genes whose overexpression can overcome NSCLC cells’ reliance EGFR. Using both unbiased and targeted approaches, demonstrate that these commonly bypass through reactivation downstream signaling pathways.