Clearance of pathological antibodies using biomimetic nanoparticles

• DOI: 10.1073/pnas.1412420111
• Publication Date: 2014-09-03T03:56:19Z
• Authors: Jonathan A. Copp; Ronnie H. Fang; Brian T. Luk; Che-Ming J. Hu; Weiwei Gao; Kang Zhang; Liangfang Zhang
• Keywords: 0301 basic medicine; Mice; 03 medical and health sciences; Erythrocytes; Biomimetics; Animals; Nanoparticles; Autoimmunity; Antibodies, Neutralizing; Antibodies; 3. Good health

Significance The selective depletion of disease-causing antibodies using nanoparticles offers a new model in the management of type II immune hypersensitivity reactions. The demonstration of pathophysiologically inspired nanoengineering serves as a valuable prototype for additional therapeutic improvements with the goal of minimizing therapy-related adverse effects. Through the use of cell membrane-cloaked nanoparticles, nanoscale decoys with strong affinity to pathological antibodies can be administered to disrupt disease processes in a minimally toxic manner. These biomimetic nanoparticles enable indiscriminate absorption of pathological antibodies regardless of their epitope specificities. This particular approach offers much promise in treating antibody-mediated autoimmune diseases, in which target antigens on susceptible cells can vary from patient to patient.