Myosin binding protein-C activates thin filaments and inhibits thick filaments in heart muscle cells

• DOI: 10.1073/pnas.1413922112
• Publication Date: 2014-12-16T03:25:14Z
• Authors: Thomas Kampourakis; Ziqian Yan; Mathias Gautel; Yin-Biao Sun; Malcolm Irving
• Keywords: Myofilament; Myofibril

Significance Myosin binding protein-C (MyBP-C) is a regulatory protein of heart muscle. Mutations in MyBP-C are frequently associated with disease, but the mechanism action poorly understood. By characterizing effects its N-terminal domains on structures thin and thick filaments contracting muscle cells, we showed that stabilizes ON state OFF filaments. The results lead to model for control contraction which functions coordinated by MyBP-C, providing an integrated framework design development therapeutic interventions disease.