Inhibition of tumor cell proliferation and motility by fibroblasts is both contact and soluble factor dependent
0301 basic medicine
Contact Inhibition
Reverse Transcriptase Polymerase Chain Reaction
Gene Expression Profiling
Fibroblasts
Coculture Techniques
Cell Line
Extracellular Matrix
3. Good health
Luminescent Proteins
Mice
03 medical and health sciences
Microscopy, Fluorescence
Cell Movement
Cell Line, Tumor
Culture Media, Conditioned
Animals
Humans
Cells, Cultured
Cell Proliferation
Oligonucleotide Array Sequence Analysis
Red Fluorescent Protein
DOI:
10.1073/pnas.1419554111
Publication Date:
2014-11-20T08:43:24Z
AUTHORS (9)
ABSTRACT
Significance
Normal microenvironments can restrict cancer development and progression. Inhibition of tumor cell growth and motility by normal fibroblasts is one measurable manifestation of this multicomponential control. Here we show that inhibition withstands formalin fixation and can be augmented by the addition of conditioned medium derived from live cultures of tumor cells confronting the stromal fibroblasts. We describe a number of molecules involved in this process. This study lays the foundation for further mechanistic studies of this important phenomenon and its contribution to possible dormancy and the tumor’s resistance to therapy.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (25)
CITATIONS (86)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....