Antagonist of GH-releasing hormone receptors alleviates experimental ocular inflammation

• DOI: 10.1073/pnas.1421815112
• Publication Date: 2014-12-09T05:58:08Z
• Authors: Yong Jie Qin; Sun On Chan; Kelvin Kam Lung C...; Benjamin Fuk Loi Li; Tsz Kin Ng; Yolanda Wong Ying...; Haoyu Chen; Mingzhi Zhang; Norman L. Block; Herman S. Cheung; Andrew V. Schally; Chi Pui Pang
• Keywords: Proinflammatory cytokine; Growth hormone–releasing hormone

Significance We have shown that the growth hormone-releasing hormone–growth hormone–insulin-like factor-1 (GHRH–GH–IGF1) axis is involved in experimentally induced acute inflammation iris and ciliary body, where its activation associated with inflammatory responses. Blocking GHRH–GH–IGF1 activity by GHRH receptor (GHRH-R) antagonist effective alleviating These findings demonstrate a novel of signaling ocular suggest potential therapeutic application GHRH-R antagonist.