Asphyxia-activated corticocardiac signaling accelerates onset of cardiac arrest

• DOI: 10.1073/pnas.1423936112
• Publication Date: 2015-04-07T02:23:05Z
• Authors: Duan Li; Omar S. Mabrouk; Tiecheng Liu; Fangyun Tian; Gang Xu; Santiago Rengifo; Sarah J. Choi; Abhay Mathur; Charles P. Crooks; Robert T. Kennedy; Michael M. Wang; Hamid Ghanbari; Jimo Borjigin
• Keywords: Neurochemical; Brain damage; Hypoxia; Perinatal asphyxia

Significance How does the heart of a healthy individual cease to function within just few minutes in absence oxygen? We addressed this issue by simultaneously examining and brain animal models during asphyxiation found that asphyxia markedly stimulates neurophysiological neurochemical activities brain. Furthermore, previously unidentified corticocardiac coupling showed increased intensity as deteriorated. Blocking efferent input survival time both The results show targeting brain’s outflow may be an effective strategy delay death from asphyxia.