BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase

• DOI: 10.1073/pnas.1424705112
• Publication Date: 2015-06-23T02:01:34Z
• Authors: Abid Khan; Sumanprava Giri; Yating Wang; Arindam Chakraborty; Archit K. Ghosh; Aparna Anantharaman; Vasudha Aggarwal; Kizhakke M. Sathyan; Taekjip Ha; Kannanganattu V. ...; Supriya G. Prasanth
• Keywords: Transcription; SWI/SNF

Significance Transcriptional regulation of the rDNA cluster is a tightly regulated process owing to cellular demand for ribosomal subunits. Dysregulation biogenesis associated with genomic instability and tumor progression. Nucleolar-remodeling complex (NoRC) has emerged as key in maintenance repression. However, mechanisms that regulate association NoRC gene loci are yet be understood. We unravel role B ANP, E 5R, N ac1 (BEN) domain-containing transcription repressor, BEND3, regulating BEND3 modulates stability component, TTF-1–interacting protein 5 (Tip5), by controlling USP21-mediated deubiquitination Tip5. These results provide crucial insights into factor expression recruitment activity chromatin-modifying complex.