Regression of established tumors and metastases by potent vascular endothelial growth factor blockade

• DOI: 10.1073/pnas.1432908100
• Publication Date: 2003-06-24T17:47:39Z
• Authors: Jianzhong Huang; Jason S. Frischer; Anna Serur; Angela Kadenhe; Akiko Yokoi; Kimberly W. McCru...; Tamara New; Kathleen O'Toole; Stephanie Zabski; John S. Rudge; Jocelyn Holash; George D. Yancopo...; Darrell J. Yamashiro; Jessica J. Kandel
• Keywords: Mural cell

Vascular endothelial growth factor (VEGF) is a critical promoter of blood vessel during embryonic development and tumorigenesis. To date, studies VEGF antagonists have primarily focused on halting progression in models minimal residual cancer. Consistent with this focus, recent clinical trials suggest that blockade may impede cancer progression, presumably by preventing neoangiogenesis. However, also key mediator endothelial–vascular mural cell interactions, role contribute to the integrity mature vessels advanced tumors. Here, we report high-affinity VEGF, using recently described VEGF-Trap, abolishes mature, preexisting vasculature established xenografts. Eradication followed marked tumor regression, including regression lung micrometastases. Thus, contribution relatively low levels be maintenance even very small masses. Potent provide new therapeutic option for patients bulky, metastatic cancers.