Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae , an urgent threat to public health

• DOI: 10.1073/pnas.1501049112
• Publication Date: 2015-06-23T02:01:34Z
• Authors: Kathryn E. Holt; Heiman Wertheim; Ruth N. Zadoks; Stephen Baker; Chris A. Whitehouse; David Dance; Adam Jenney; Thomas R. Connor; Li Yang Hsu; Juliëtte Severin; Sylvain Brisse; Hanwei Cao; Jonathan Wilksch; Claire Gorrie; Mark B. Schultz; David J. Edwards; Kinh Van Nguyen; Trung Vu Nguyen; Trinh Tuyet Dao; Martijn Mensink; Vien Le Minh; Nguyen Thi Khanh Nhu; Constance Schultsz; Kuntaman Kuntaman; Paul N. Newton; Catrin E. Moore; Richard A. Strugnell; Nicholas R. Thomson
• Keywords: Population Structure

Klebsiella pneumoniae is now recognized as an urgent threat to human health because of the emergence multidrug-resistant strains associated with hospital outbreaks and hypervirulent severe community-acquired infections. K. ubiquitous in environment can colonize infect both plants animals. However, little known about population structure pneumoniae, so it difficult recognize or understand clinically important clones within this highly genetically diverse species. Here we present a detailed genomic framework for based on whole-genome sequencing more than 300 animal isolates spanning four continents. Our data provide genome-wide support splitting into three distinct species, KpI (K. pneumoniae), KpII quasipneumoniae), KpIII variicola). Further, (KpI), entity most frequently infection, show existence >150 deeply branching lineages including numerous clones. We has large accessory genome approaching 30,000 protein-coding genes, number virulence functions that are significantly invasive disease humans. In our dataset, antimicrobial resistance genes were common among carriage hospital-acquired infections, which generally lacked disease. The convergence potentially could lead untreatable infections; against track such threats.