Human Ebola virus infection results in substantial immune activation

• DOI: 10.1073/pnas.1502619112
• Publication Date: 2015-03-10T02:42:15Z
• Authors: Anita K. McElroy; Rama S. Akondy; Carl W. Davis; Ali H. Ellebedy; Aneesh K. Mehta; Colleen S. Kraft; G. Marshall Lyon; Bruce S. Ribner; Jay Varkey; John Sidney; Alessandro Sette; Shelley Campbell; Ute Ströher; Inger Damon; Stuart T. Nichol; Christina F. Spir...; Rafi Ahmed
• Keywords: Ebolavirus; Ebola vaccine; VP40

Significance In 2014, Ebola virus became a household term. The ongoing outbreak in West Africa is the largest ever recorded, with over 20,000 cases and 8,000 deaths to date. Very little known about human cellular immune response infection, this lack of knowledge has hindered development effective therapies vaccines. study, we characterize infection four patients. We define kinetics T- B-cell activation, determine which viral proteins are targets virus-specific T-cell humans.