HAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heart

• DOI: 10.1073/pnas.1508760112
• Publication Date: 2015-11-10T04:14:28Z
• Authors: Chi Keung Lam; Wen Zhao; Guan-Sheng Liu; Wen-Feng Cai; George Gardner; George Adly; Evangelia G. Kranias
• Keywords: Cyclophilin

Significance The massive cell death, associated with a heart attack, is mainly due to disruption of mitochondrial membrane integrity upon activation the permeability transition pore. Thus, it important understand how this pore regulated prevent cardiac death. In study, we reported that hematopoietic-substrate-1 protein X-1 (HAX-1) an inhibitor and promotes survival. HAX-1 works through recruitment chaperone called Hsp90 from cyclophilin-D, major component Displacement cyclophilin-D degradation, resulting in inhibition opening Given contributes various diseases, our findings have broader applications reaching beyond heart.