Bioengineered yeast-derived vacuoles with enhanced tissue-penetrating ability for targeted cancer therapy

• DOI: 10.1073/pnas.1509371113
• Publication Date: 2015-12-30T02:44:36Z
• Authors: Vipul Gujrati; Miriam Lee; Young-Joon Ko; Sangeun Lee; Daejin Kim; Hyungjun Kim; Sukmo Kang; Soyoung Lee; Jinjoo Kim; Hyungsu Jeon; Sun Chang Kim; Youngsoo Jun; Sangyong Jon
• Keywords: Nanocarriers; Cancer Therapy; Targeted drug delivery; Budding yeast

Significance Tumor tissues have formidable physiological barriers, such as a high interstitial pressure and densely entangled ECM. Most synthetic nanomaterials used for drug delivery fail to penetrate tumor deeply localize only in perivascular areas, thereby limiting their therapeutic efficacy. This report describes bioengineered yeast-derived natural nanocarriers cancer-specific targeting delivery. Budding yeast was genetically engineered produce large numbers of nanosized compartments—vacuoles that display cancer—targeting ligands on surface. The vacuoles significantly enhanced penetration xenografts, consequently prevented growth without eliciting immune responses. result shows the biological overcome limitations associated with cancer-targeting nanomaterials, thus can be treat various cancers.