A role for CD36 in the regulation of dendritic cell function

• DOI: 10.1073/pnas.151028698
• Publication Date: 2002-07-26T14:34:10Z
• Authors: Britta C. Urban; Nick Willcox; David J. Roberts
• Keywords: CD36

Dendritic cells (DC) are crucial for the induction of immune responses and thus an inviting target modulation by pathogens. We have previously shown that Plasmodium falciparum -infected erythrocytes inhibit maturation DCs. Intact P. can bind directly to CD36 indirectly CD51. It is striking these receptors, at least in part, also mediate phagocytosis apoptotic cells. Here we show antibodies against or CD51, as well exposure early cells, profoundly modulate DC function response inflammatory signals. Although modulated DCs still secrete tumor necrosis factor-α, they fail activate T now IL-10. therefore propose intact engage similar pathways regulating function. These findings may important consequences treatment malaria suggest strategies modulating pathological autoimmune diseases.