Interleukin-11 alters placentation and causes preeclampsia features in mice

Placentation Spiral artery Trophoblast Decidua Interleukin 11
DOI: 10.1073/pnas.1515076112 Publication Date: 2015-12-12T03:49:00Z
ABSTRACT
Significance Preeclampsia is an insidious disease, unique to humans, affecting ∼8% of pregnancies. There are no early detection tests or pharmacological treatments. Impaired placentation widely accepted contribute the pathogenesis. However, mechanisms remain elusive, given complications studying first-trimester placental development in women. A major limitation for study new treatments lack available animal models that recapitulate full spectrum preeclampsia features. We have developed a mouse model characterized by elevated levels cytokine Interleukin-11 (IL11). This provides evidence novel pathway causative features vivo . It also useful preclinical studies test potential therapeutics.
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