Interleukin-11 alters placentation and causes preeclampsia features in mice

Male 0301 basic medicine Placenta Blotting, Western Enzyme-Linked Immunosorbent Assay 03 medical and health sciences Pre-Eclampsia Pregnancy Decidua Animals Humans Pregnancy-Associated Plasma Protein-A Receptors, Interleukin-11 Reverse Transcriptase Polymerase Chain Reaction Trophoblast Gene Expression Regulation, Developmental Interleukin-11 Immunohistochemistry Placentation Recombinant Proteins Mice, Inbred C57BL 1000 General Cytokines Female RNA Interference
DOI: 10.1073/pnas.1515076112 Publication Date: 2015-12-12T03:49:00Z
ABSTRACT
Significance Preeclampsia is an insidious disease, unique to humans, affecting ∼8% of pregnancies. There are no early detection tests or pharmacological treatments. Impaired placentation is widely accepted to contribute to the pathogenesis. However, the mechanisms remain elusive, given the complications of studying first-trimester placental development in women. A major limitation for the study of new treatments is the lack of available animal models that recapitulate the full spectrum of preeclampsia features. We have developed a mouse model characterized by elevated levels of the cytokine Interleukin-11 (IL11). This study provides evidence of a novel pathway causative of preeclampsia features in vivo . It also provides a novel in vivo mouse model that is useful for preclinical studies to test potential therapeutics.
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