Interleukin-11 alters placentation and causes preeclampsia features in mice
Male
0301 basic medicine
Placenta
Blotting, Western
Enzyme-Linked Immunosorbent Assay
03 medical and health sciences
Pre-Eclampsia
Pregnancy
Decidua
Animals
Humans
Pregnancy-Associated Plasma Protein-A
Receptors, Interleukin-11
Reverse Transcriptase Polymerase Chain Reaction
Trophoblast
Gene Expression Regulation, Developmental
Interleukin-11
Immunohistochemistry
Placentation
Recombinant Proteins
Mice, Inbred C57BL
1000 General
Cytokines
Female
RNA Interference
DOI:
10.1073/pnas.1515076112
Publication Date:
2015-12-12T03:49:00Z
AUTHORS (12)
ABSTRACT
Significance
Preeclampsia is an insidious disease, unique to humans, affecting ∼8% of pregnancies. There are no early detection tests or pharmacological treatments. Impaired placentation is widely accepted to contribute to the pathogenesis. However, the mechanisms remain elusive, given the complications of studying first-trimester placental development in women. A major limitation for the study of new treatments is the lack of available animal models that recapitulate the full spectrum of preeclampsia features. We have developed a mouse model characterized by elevated levels of the cytokine Interleukin-11 (IL11). This study provides evidence of a novel pathway causative of preeclampsia features in vivo
.
It also provides a novel in vivo mouse model that is useful for preclinical studies to test potential therapeutics.
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CITATIONS (73)
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