Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain

• DOI: 10.1073/pnas.1532244100
• Publication Date: 2003-07-22T19:39:06Z
• Authors: Maurice A. Curtis; Ellen B. Penney; Andree G. Pearson; Willeke M. C. van...; Niqi J. Butterworth; Michael Dragunow; Bronwen Connor; Richard L. M. Faull
• Keywords: Human brain; Proliferation Marker

Neurogenesis has recently been observed in the adult human brain, suggesting possibility of endogenous neural repair. However, augmentation neurogenesis brain response to neuronal cell loss not demonstrated. This study was undertaken investigate whether occurs subependymal layer (SEL) adjacent caudate nucleus neurodegeneration Huntington's disease (HD). Postmortem control and HD tissue were examined by using cycle marker proliferating nuclear antigen (PCNA), βIII-tubulin, glial fibrillary acidic protein (GFAP). We a significant increase proliferation SEL compared with brains. Within group, degree increased pathological severity increasing CAG repeats gene. Most importantly, PCNA + cells shown coexpress βIII-tubulin or GFAP, demonstrating generation neurons diseased brain. Our results provide evidence progenitor further indicate regenerative potential