Keratin mediates the recognition of apoptotic and necrotic cells through dendritic cell receptor DEC205/CD205

• DOI: 10.1073/pnas.1609331113
• Publication Date: 2016-11-08T03:55:04Z
• Authors: Longxing Cao; Haishuang Chang; Xiangyi Shi; Chao Peng; Yongning He
• Keywords: 0301 basic medicine; Glycoside Hydrolases; Apoptosis; Receptors, Cell Surface; Dendritic Cells; Hydrogen-Ion Concentration; Ligands; 3. Good health; Mice, Inbred C57BL; Minor Histocompatibility Antigens; Jurkat Cells; Necrosis; 03 medical and health sciences; HEK293 Cells; Antigens, CD; Animals; Humans; Keratins; Lectins, C-Type; Protein Binding

Significance DEC205 (CD205) is an endocytotic receptor on dendritic cells that recognizes dead in a pH-dependent fashion and has been widely used for vaccine generation immune therapies. However, the physiological ligand(s) of remained unknown decades. Here we identify keratins are cellular ligands human specifically at acidic pH. Keratins structural proteins providing mechanical support tissues. Our results suggest act as markers environments. Moreover, since have diagnostic various tumors, finding scavenging may provide insights therapeutic strategies against tumors other related diseases.