Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia
0301 basic medicine
aquaporin-3
Colon
Knockout
Physiological
hydrogen peroxide
Stress
Oral and gastrointestinal
Mice
03 medical and health sciences
Stress, Physiological
2.1 Biological and endogenous factors
Innate
Animals
Humans
Aetiology
Intestinal Mucosa
Immunity, Mucosal
Cancer
Mice, Knockout
Mucosal
Aquaporin 3
Wound Healing
0303 health sciences
colon
Inflammatory and immune system
Inflammatory Bowel Disease
Immunity
Hydrogen Peroxide
Immunity, Innate
Colo-Rectal Cancer
3. Good health
microbe
Gene Knockdown Techniques
Citrobacter rodentium
Caco-2 Cells
Digestive Diseases
epithelium
Signal Transduction
DOI:
10.1073/pnas.1612921114
Publication Date:
2017-01-04T01:50:20Z
AUTHORS (5)
ABSTRACT
Significance
The extracellular production of hydrogen peroxide (H
2
O
2
) by membrane or secreted oxidases has been linked to epithelial wound repair, defense against infection, and inflammation. Here, we elucidate the pathway that explains how extracellular H
2
O
2
transduces a signal into the cell to induce these critical cell functions. Our study shows the central component of this pathway in the mammalian colon is the H
2
O
2
-conducting aquaglyceroporin AQP3 and implicates this channel in innate immune responses at mucosal surfaces.
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CITATIONS (91)
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