Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia

0301 basic medicine aquaporin-3 Colon Knockout Physiological hydrogen peroxide Stress Oral and gastrointestinal Mice 03 medical and health sciences Stress, Physiological 2.1 Biological and endogenous factors Innate Animals Humans Aetiology Intestinal Mucosa Immunity, Mucosal Cancer Mice, Knockout Mucosal Aquaporin 3 Wound Healing 0303 health sciences colon Inflammatory and immune system Inflammatory Bowel Disease Immunity Hydrogen Peroxide Immunity, Innate Colo-Rectal Cancer 3. Good health microbe Gene Knockdown Techniques Citrobacter rodentium Caco-2 Cells Digestive Diseases epithelium Signal Transduction
DOI: 10.1073/pnas.1612921114 Publication Date: 2017-01-04T01:50:20Z
ABSTRACT
Significance The extracellular production of hydrogen peroxide (H 2 O 2 ) by membrane or secreted oxidases has been linked to epithelial wound repair, defense against infection, and inflammation. Here, we elucidate the pathway that explains how extracellular H 2 O 2 transduces a signal into the cell to induce these critical cell functions. Our study shows the central component of this pathway in the mammalian colon is the H 2 O 2 -conducting aquaglyceroporin AQP3 and implicates this channel in innate immune responses at mucosal surfaces.
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