Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia
Aquaporin 3
DOI:
10.1073/pnas.1612921114
Publication Date:
2017-01-04T01:50:20Z
AUTHORS (5)
ABSTRACT
Significance The extracellular production of hydrogen peroxide (H 2 O ) by membrane or secreted oxidases has been linked to epithelial wound repair, defense against infection, and inflammation. Here, we elucidate the pathway that explains how H transduces a signal into cell induce these critical functions. Our study shows central component this in mammalian colon is -conducting aquaglyceroporin AQP3 implicates channel innate immune responses at mucosal surfaces.
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