Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia

• DOI: 10.1073/pnas.1612921114
• Publication Date: 2017-01-04T01:50:20Z
• Authors: Jay R. Thiagarajah; Jeffrey Chang; Jeremy A. Goettel; Alan S. Verkman; Wayne I. Lencer
• Keywords: Aquaporin 3

Significance The extracellular production of hydrogen peroxide (H 2 O ) by membrane or secreted oxidases has been linked to epithelial wound repair, defense against infection, and inflammation. Here, we elucidate the pathway that explains how H transduces a signal into cell induce these critical functions. Our study shows central component this in mammalian colon is -conducting aquaglyceroporin AQP3 implicates channel innate immune responses at mucosal surfaces.