Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis

• DOI: 10.1073/pnas.1614035114
• Publication Date: 2017-01-04T01:50:20Z
• Authors: Peiwen Chen; Hao Zuo; Hu Xiong; Matthew J. Kolar; Qian Chu; Alan Saghatelian; Daniel J. Siegwart; Yihong Wan
• Keywords: Breast cancer metastasis

Significance Metastasis is a major cause of cancer mortality. However, the regulation this complex process remains poorly understood. Due to low oxygen supply and enhanced sugar metabolism, cells releases lactate create an acidic environment. We show that membrane receptor on macrophages called G protein-coupled 132 (Gpr132) can sense respond signal from cells. As result, alter their functions, which, in turn, stimulates metastasis distant organs. Consequently, loss Gpr132 mice inhibits breast metastasis; lower expression patients with correlates better metastasis-free survival. These findings uncover knowledge potentially novel treatment for metastasis.