Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells

• DOI: 10.1073/pnas.1615730114
• Publication Date: 2017-06-06T00:50:17Z
• Authors: Davide Genini; Lara Brambilla; Erik Laurini; Jessica Merulla; Gianluca Civenni; Shusil Pandit; Rocco D'Antuono; Laurent Perez; David E. Levy; Sabrina Pricl; Giuseppina M. Car...; Carlo V. Catapano
• Keywords: Synthetic Lethality; Lethality

Significance The transcription factor STAT3 is involved in multiple oncogenic signaling pathways and an attractive therapeutic target. This study shows that a potent inhibitor of interferes with mitochondrial activity protein homeostasis, leading to synthetic lethality effect glucose-depleted cancer cells. These findings provide rationale for novel strategies based on the use inhibitors treatment.