Dnmt3a restrains mast cell inflammatory responses

• DOI: 10.1073/pnas.1616420114
• Publication Date: 2017-02-07T02:05:30Z
• Authors: Cristina Leoni; Sara Montagner; Andrea Rinaldi; Francesco Bertoni; Sara Polletti; Chiara Balestrieri; Silvia Monticelli
• Keywords: Mast (botany)

Significance Methylation of genomic DNA is an epigenetic modification at the interface between genetic information and environmental stimuli underlying many phenotypic variations in human population as well pathogenesis complex diseases. Accordingly, mutations de novo methyltransferase enzyme DNMT3A have been identified a number diseases, including mast cell-related disorders. However, role methylation regulating cell physiology still needs to be elucidated. Here, we found that Dnmt3a plays critical modulating responsiveness acute chronic stimulation, potentially implicating methylation-mediated processes all types