Integrated view of internal friction in unfolded proteins from single-molecule FRET, contact quenching, theory, and simulations

• DOI: 10.1073/pnas.1616672114
• Publication Date: 2017-02-22T01:40:29Z
• Authors: Andrea Soranno; Andrea Holla; Fabian Dingfelder; Daniel Nettels; Dmitrii E. Makarov; Benjamin Schuler
• Keywords: Folding (DSP implementation); Internal friction

Significance The dynamics of proteins, which are essential for both folding and function, known to be strongly dependent on solvent viscosity friction. However, an increasing number experiments have demonstrated the importance a contribution protein independent Such “internal friction” has recently been detected even in unfolded although they more expanded solvent-accessible than folded proteins. Based two complementary experimental methods, simulations, theory, our results provide coherent view internal friction proteins constitute important basis understanding molecular origin this phenomenon its role functional intrinsically disordered