Influenza A surface glycosylation and vaccine design

• DOI: 10.1073/pnas.1617174114
• Publication Date: 2016-12-28T01:50:24Z
• Authors: Chung-Yi Wu; Chih-Wei Lin; Tsung-I Tsai; Chang-Chun David Lee; Hong-Yang Chuang; Jhih-Bin Chen; Ming-Hung Tsai; Bo-Rui Chen; Pei-Wen Lo; Chiu-Ping Liu; Vidya S. Shivatare; Chi-Huey Wong
• Keywords: N-linked glycosylation; Infectivity

Significance Influenza A virus (IAV) is a major threat to global public health, and so understanding the biology of IAV essential develop antiflu vaccines therapeutics. Here, we show links between viral surface glycosylation function. The HA modulates infectivity, host immune response; NA affects its structure, activity, specificity, thermostability regulate release virulence. In addition, using live attenuated without stalk catalytic domains as vaccine can strongly induce IAV-specific CD8 + T-cell responses various strains. Therefore, our findings have clarified role in provided new direction for development universal flu vaccines.