Up-regulation of CD81 inhibits cytotrophoblast invasion and mediates maternal endothelial cell dysfunction in preeclampsia

• DOI: 10.1073/pnas.1617601114
• Publication Date: 2017-02-07T02:05:30Z
• Authors: Li Shen; Zhenyu Diao; Hai-Xiang Sun; Gui-Jun Yan; Zhiqun Wang; Ruo-Tian Li; Yimin Dai; Jingmei Wang; Jie Li; Hailing Ding; Guangfeng Zhao; Mingming Zheng; Pingping Xue; Mo Liu; Yan Zhou; Yali Hu
• Keywords: Syncytiotrophoblasts; Placentation; CTBS; Cytotrophoblast; CD81; Syncytiotrophoblasts

Significance Preeclampsia (PE) is a severe trophoblast-related disorder that threatens the health of mother and fetus. Impaired placentation in early stages pregnancy subsequent systemic endothelial cell activation constitute principle pathogenic mechanisms PE. Currently, molecules involved pathogenesis PE link two this remain elusive. Our study demonstrates CD81 associated with key pathological changes occur both placenta maternal cells patients (sPE). Importantly, overexpression induces PE-like phenotype pregnant rats. This provides evidence involvement supports use as potential biomarker for