Transcriptional landscape of the human cell cycle

• DOI: 10.1073/pnas.1617636114
• Publication Date: 2017-03-14T01:09:36Z
• Authors: Yin Liu; Sujun Chen; Su Wang; Fraser Soares; Martin Fischer; Feilong Meng; Zhou Du; Charles Lin; Clifford Meyer; James A. DeCaprio; Myles Brown; X. Shirley Liu; Housheng Hansen He
• Keywords: Transcription

Significance Our study provided a comprehensive view of the transcriptional landscape across cell cycle. We revealed lag between transcription and steady-state RNA expression at cell-cycle level characterized large amount active during early mitosis. In addition, our analysis identified thousands enhancer RNAs related factors that are highly correlated with cell-cycle–regulated but not expression, thus highlighting importance epigenetic dynamics progression.