Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis

Malate synthase Assimilation (phonology) Detoxification Coenzyme A
DOI: 10.1073/pnas.1617655114 Publication Date: 2017-03-07T02:00:34Z
ABSTRACT
Significance A better understanding of essential processes in Mycobacterium tuberculosis ( Mtb ) is required for the development new chemotherapeutics. Isocitrate lyase (ICL) and malate synthase (MS) function glyoxylate shunt, a pathway by to metabolize fatty acids (FAs). Here, we demonstrate that MS enables growth survival on through its ability simultaneously detoxify metabolic byproduct arising from initial assimilation acetyl coenzyme (acetyl-CoA), glyoxylate, while assimilating second molecule acetyl-CoA. We further show depletion during acute chronic mouse infections kills . These studies expand our fundamental shunt biologically validate as an attractive drug target
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