Characterization of cytopathic factors through genome-wide analysis of the Zika viral proteins in fission yeast

• DOI: 10.1073/pnas.1619735114
• Publication Date: 2017-01-04T01:50:20Z
• Authors: Ge Li; Melissa Poulsen; Csaba Fenyvuesvolgyi; Yoko Yashiroda; Minoru Yoshida; J. Marc Simard; Robert C. Gallo; Richard Y. Zhao
• Keywords: Microcephaly

Significance The Zika virus (ZIKV) causes various neurologic defects including microcephaly and the Guillain-Barré syndrome. However, little is known about how ZIKV those diseases or which viral protein(s) responsible for observed cytopathic effects involved in restricted neuronal cellular growth, dysregulation of cell cycle, induction hypertrophy death. A genome-wide analysis proteins peptides was conducted using fission yeast as a surrogate host. Seven conferred NS4A-induced growth restriction were mediated through target rapamycin (TOR) stress-response pathway. These findings provide foundation identifying pathogenicity factors associated with diseases.