RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa

• DOI: 10.1073/pnas.1700286114
• Publication Date: 2017-07-04T00:50:19Z
• Authors: Luke P. Allsopp; Thomas E. Wood; Sophie A. Howard; Federica Maggiorelli; Laura M. Nolan; Sarah Wettstadt; Alain Filloux
• Keywords: Priming (agriculture)

Significance Bacteria evolved molecular weapons to help them thrive in polymicrobial environments. The type VI secretion system (T6SS) is a gun loaded with great diversity of bacterial toxins. On contact neighboring cells, toxins are fired, and the absence immunity, prey killed, allowing attacker prevail. Each bacterium can be equipped several distinct T6SSs, it unclear whether they simultaneously active or each has specific role particular environment. Here we showed that production three Pseudomonas aeruginosa T6SSs orchestrated by global regulators. We suggest may possible for simultaneous assembly multiple within single cell, priming fight wide variety organisms.