Fold-change detection and scale invariance of cell–cell signaling in social amoeba

• DOI: 10.1073/pnas.1702181114
• Publication Date: 2017-05-12T01:10:33Z
• Authors: Keita Kamino; Yohei Kondo; Akihiko Nakajima; Mai Honda-Kitahara; Kunihiko Kaneko; Satoshi Sawai
• Keywords: Multicellular organism; Robustness; Cell Signaling; Stimulus (psychology)

Significance Recent works have hinted at an ability of cells to respond in the exact same manner a fold change input stimulus. The property is thought allow function properly regardless changes absolute concentrations signaling molecules. Despite its general importance, however, evidence has remained scarce. present work demonstrated that, social amoeba Dictyostelium , response cell–cell communication molecules fold-change dependent and that this tightly linked condition allows them oscillate collectively, thus organize into multicellular form. Such properties may be importance for robustness other developmental systems where oscillatory plays pivotal role defining organization.