Targeting cancer cell integrins using gold nanorods in photothermal therapy inhibits migration through affecting cytoskeletal proteins

• DOI: 10.1073/pnas.1703151114
• Publication Date: 2017-06-27T00:40:30Z
• Authors: Moustafa R. K. Ali; Yue Wu; Yan Tang; Haopeng Xiao; Kuangcai Chen; Tiegang Han; Ning Fang; Ronghu Wu; Mostafa A. El-Sayed
• Keywords: Nanorod; Cancer Therapy

Significance Metastasis is the primary cause of cancer-related deaths. Current clinical treatments for antimetastasis, however, are not effective. This work aims to develop a strategy inhibit cancer cell migration using gold nanorods (AuNRs) with systematic understanding mechanism. The ability targeting AuNRs surface integrins and introduction NIR light generate mild plasmonic photothermal effect caused broad regulation on cytoskeletal proteins, thus impairing migration. provides potential application controlling metastasis.