Interferon-γ is a master checkpoint regulator of cytokine-induced differentiation

• DOI: 10.1073/pnas.1706915114
• Publication Date: 2017-08-01T00:50:22Z
• Authors: Zhao Zha; Felicitas Bucher; Anahita Nejatfard; Tianqing Zheng; Hongkai Zhang; Kyungmoo Yea; Richard A. Lerner
• Keywords: Master regulator; Internalization; Glycoprotein 130; Cytokine receptor

Significance The understanding of the molecular mechanisms activation and checkpoint processes has important therapeutic implications. Here, we show that interferon-γ is a master regulator for many cytokines. It operates partially by activating STAT1 signaling. However, most mechanism allows it to assume status. To do this, induces internalization gp130, common component heterodimeric cytokine receptors. Therefore, this could open whole new paradigm in cell biology.