Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes
Immunosuppression Therapy
Primates
1000 Multidisciplinary
0303 health sciences
Swine
Diabetes
Transplantation, Heterologous
10265 Clinic for Endocrinology and Diabetology
Islets of Langerhans Transplantation
610 Medicine & health
Porcine islets
Diabetes Mellitus, Experimental
3. Good health
Islets of Langerhans
03 medical and health sciences
Diabetes Mellitus, Type 1
Beta-cell replacement
Diabetes ; Porcine Islets ; Beta-cell Replacement ; Immune Barrier
616
617
Animals
Female
Immune barrier
DOI:
10.1073/pnas.1708420114
Publication Date:
2017-10-16T19:21:05Z
AUTHORS (23)
ABSTRACT
Significance
Diabetes mellitus type 1 is an autoimmune disease that results in irreversible destruction of insulin-producing beta cells. Substantial advances have been made in beta cell replacement therapies during the last decades. However, lack of eligible donor organs and the need for chronic immunosuppression to prevent rejection critically limit widespread application of these strategies. In this manuscript, we present an experimental study using a bioartificial pancreas device for the transplantation of xenogeneic islet without affecting the immune system in nonhuman primates. We could demonstrate stable graft function and adequate glucose-regulated insulin secretion without the need for immunosuppressive medication. This strategy opens up new avenues for more widespread and safe application of various cell-based therapies.
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CITATIONS (101)
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