Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer

• DOI: 10.1073/pnas.1712946114
• Publication Date: 2017-10-23T20:05:28Z
• Authors: Xiang Xue; Bryce X. Bredell; Erik R. Anderson; Angelical Martin; Christopher Mays; Hiroko Nagao-Kita...; Sha Huang; Balázs Győrffy; Joel K. Greenson; Karin Hardiman; Jason R. Spence; Nobuhiko Kamada; Yatrik M. Shah
• Keywords: Inflammation; Proteomics; 0301 basic medicine; Carcinogenesis; Iron; Membrane Proteins; Mice, Transgenic; Inflammatory Bowel Diseases; Mitochondria; 3. Good health; Disease Models, Animal; Mice; 03 medical and health sciences; Colonic Neoplasms; Animals; Homeostasis; Humans; Reactive Oxygen Species

Significance Inflammation is a major risk factor for many cancers and the role of metabolic reprogramming in inflammatory progression cancer not clear. We used quantitative proteomic approach to identify mitochondrial proteins that are altered early intestinal inflammation. show iron dysregulation an event initiates dysfunction. Through analysis, we identified reductase, six-transmembrane epithelial antigen prostate 4 (STEAP4), as being highly elevated during Using epithelial-specific STEAP4 mice, increase sufficient alter homeostasis. Chronic leads tissue injury potentiates colon cancer, whereas chelation protective colitis colitis-associated models.