Sex bias in MHC I-associated shaping of the adaptive immune system

• DOI: 10.1073/pnas.1716146115
• Publication Date: 2018-02-12T20:25:12Z
• Authors: Tilman Schneider-...; Dennis Görlich; Paula Savola; Tiina Kelkka; Satu Mustjoki; Catharina C. Gross; Geoffrey C. Owens; Luisa Klotz; Klaus Dornmair; Heinz Wiendl; Nicholas Schwab
• Keywords: rheumatoid arthritis; Adult; Male; autoimmunity; Genes, MHC Class I; immunological sex bias; Adaptive Immunity; multiple sclerosis; 3. Good health; MHC Class I; 03 medical and health sciences; Sex Factors; 0302 clinical medicine; Genes; Humans; T cell receptor repertoire; Female; 10. No inequality

Significance Our analysis shows that sex can be associated with the degree to which HLA molecules propagate selection and expansion of T cells as characterized by their cell receptor variable beta chain (TCRBV). Furthermore, CD8 cells, especially in men autoimmune diseases such multiple sclerosis or rheumatoid arthritis, are capable expanding unison other even without expressing TCRBVs biochemical similarity pivotal HLA-binding regions. findings add understanding bias immune system involvement: autoimmunity, infection, cancer. These results also reveal pathology-associated interest for future studies support argument sex-separated disease associations general.